Regulation of COX Assembly and Function by Twin CX9C Proteins-Implications for Human Disease.

ABSTRACT: Oxidative phosphorylation is a tightly regulated process in mammals that takes place in and across the inner mitochondrial membrane and consists of the electron transport chain and ATP synthase. Complex IV, or cytochrome c oxidase (COX), is the terminal enzyme of the electron transport chain, responsible for accepting electrons from cytochrome c, pumping protons to contribute to the gradient utilized by ATP synthase to produce ATP, and reducing oxygen to water. As such, COX is tightly regulated through numerous mechanisms including protein-protein interactions. The twin CX9C family of proteins has recently been shown to be involved in COX regulation by assisting with complex assembly, biogenesis, and activity. The twin CX9C motif allows for the import of these proteins into the intermembra

SUBMITTER: Gladyck S 

PROVIDER: S-EPMC7909247 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature