Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases.

ABSTRACT: Respiratory disorders are among the most important medical problems threatening human life. The conventional therapeutics for respiratory disorders are hindered by insufficient drug concentrations at pathological lesions, lack of cell-specific targeting, and various biobarriers in the conducting airways and alveoli. To address these critical issues, various nanoparticle delivery systems have been developed to serve as carriers of specific drugs, DNA expression vectors, and RNAs. The unique properties of nanoparticles, including controlled size and distribution, surface functional groups, high payload capacity, and drug release triggering capabilities, are tailored to specific requirements in drug/gene delivery to overcome major delivery barriers in pulmonary diseases. To avoid off-target e

SUBMITTER: Deng Z 

PROVIDER: S-EPMC7909340 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature