Lymphocyte Immune Response and T Cell Differentiation in Fontan Patients with protein-losing enteropathy.

ABSTRACT:

Background

Protein-losing enteropathy (PLE) is a severe complication of the Fontan circulation. There is increasing discussion about whether lymphatic dysregulation is involved as pathomechanism of PLE. This investigation focuses on the interplay between alteration of lymphatic cells and immunologic pathway alterations.

Methods

Micro-ribonucleic acid (miRNA) expression profiling was performed in 49 patients (n = 10 Fontan patients with PLE, n = 30 Fontan patients without PLE, and n = 9 patients with dextro-transposition of the great arteries (dTGA). miRNA pathway analysis was performed to identify significantly enriched pathways. To determine lymphocyte populations and subtypes multiparameter flow cytometry was used.

Results

miRNAs pathway analysi

SUBMITTER: Moosmann J 

PROVIDER: S-EPMC7909601 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature