On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling.

ABSTRACT: During developmental angiogenesis, endothelial cells respond to shear stress by migrating and remodelling the initially hyperbranched plexus, removing certain vessels whilst maintaining others. In this study, we argue that the key regulator of vessel preservation is cell decision behaviour at bifurcations. At flow-convergent bifurcations where migration paths diverge, cells must finely tune migration along both possible paths if the bifurcation is to persist. Experiments have demonstrated that disrupting the cells' ability to sense shear or the junction forces transmitted between cells impacts the preservation of bifurcations during the remodelling process. However, how these migratory cues integrate during cell decision making remains poorly understood. Therefore, we present the first age

SUBMITTER: Edgar LT 

PROVIDER: S-EPMC7909651 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature