Avidin-biotin complex-based capture coating platform for universal Influenza virus immobilization and characterization.

ABSTRACT: Influenza virus mutates quickly and unpredictably creating emerging pathogenic strains that are difficult to detect, diagnose, and characterize. Conventional tools to study and characterize virus, such as next generation sequencing, genome amplification (RT-PCR), and serological antibody testing, are not adequately suited to rapidly mutating pathogens like Influenza virus where the success of infection heavily depends on the phenotypic expression of surface glycoproteins. Bridging the gap between genome and pathogenic expression remains a challenge. Using sialic acid as a universal Influenza virus binding receptor, a novel virus avidin-biotin complex-based capture coating was developed and characterized that may be used to create future diagnostic and interrogation platforms for viable who

SUBMITTER: Trexler M 

PROVIDER: S-EPMC7909696 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature