Model-Based Prediction to Evaluate Residence Time of Hyaluronic Acid Based Dermal Fillers.

ABSTRACT: Dermal fillers are gel-type substances for nonsurgical medical-device use to achieve facial rejuvenation. Currently, the most widely used skin fillers are hyaluronic-acid-based dermal fillers. This study aimed to explain the change in the volume of injected dermal fillers by developing a mathematical kinetic model for various dermal fillers. The kinetics of the injected fillers were separated by a biphasic phenomenon. We attributed an increase in filler volume to the hydration of hyaluronic acid molecules and injection-site reaction and a decrease in volume to enzyme-mediated degradation. To explain these in vivo characteristics of dermal fillers, we proposed a two-compartment model, divided into a depot compartment (where the filler was injected) and a subcutaneous compartment (an observa

SUBMITTER: Ryu HJ 

PROVIDER: S-EPMC7909806 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature