Tai Forest Virus Does Not Cause Lethal Disease in Ferrets.

ABSTRACT: Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates. Among these viruses, those belonging to the Ebolavirus genus-particularly Ebola virus, Sudan virus, and Bundibugyo virus-represent some of the most pathogenic to humans. Taï Forest virus (TAFV) is thought to be among the least pathogenic ebolaviruses; however, only a single non-fatal case has been documented in humans, in 1994. With the recent success of the ferret as a lethal model for a number of ebolaviruses, we set out to evaluate its suitability as a model for TAFV. Our results demonstrate that, unlike other ebolaviruses, TAFV infection in ferrets does not result in lethal disease. None of the intramuscul

SUBMITTER: Schiffman Z 

PROVIDER: S-EPMC7909818 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature