Allergic reactions to asparaginase: retrospective cohort study in pediatric patients with acute lymphoid leukemia.

ABSTRACT:

Introduction

To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients.

Method

The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records.

Results

Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) ad

SUBMITTER: Battistel AP 

PROVIDER: S-EPMC7910154 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature