PET/CT Imaging of ⁸⁹Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys.

ABSTRACT:

Purpose

Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients. Factors contributing to this variability are PD-L1 expression levels and immune cells present in tumors. However, it is not well understood how PD-1 expression in the tumor microenvironment impacts immunotherapy response. Thus, imaging of PD-1-expressing immune cells is of interest. This study aims to evaluate the biodistribution of Zirconium-89 (⁸⁹Zr)-labeled pembrolizumab, a humanized IgG4 kappa monoclonal antibody targeting PD-1, in healthy cynomolgus monkeys as a translational model of tracking PD-1-positive immune cells.

Procedures

Pembrolizumab was

SUBMITTER: Li W 

PROVIDER: S-EPMC7910264 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature