Chromatin information content landscapes inform transcription factor and DNA interactions.

ABSTRACT: Interactions between transcription factors and chromatin are fundamental to genome organization and regulation and, ultimately, cell state. Here, we use information theory to measure signatures of organized chromatin resulting from transcription factor-chromatin interactions encoded in the patterns of the accessible genome, which we term chromatin information enrichment (CIE). We calculate CIE for hundreds of transcription factor motifs across human samples and identify two classes: low and high CIE. The 10-20% of common and tissue-specific high CIE transcription factor motifs, associate with higher protein-DNA residence time, including different binding site subclasses of the same transcription factor, increased nucleosome phasing, specific protein domains, and the genetic control of both

SUBMITTER: D'Oliveira Albanus R 

PROVIDER: S-EPMC7910283 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature