Habitual coffee intake and risk for nonalcoholic fatty liver disease: a two-sample Mendelian randomization study.

ABSTRACT:

Purpose

Epidemiological studies support a protective role of habitual coffee and caffeine consumption against the risk of non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the causal relationship between coffee intake and the risk of NAFLD.

Methods

We performed a two-sample Mendelian randomization (MR) analysis using SNPs associated with habitual coffee intake in a published genome-wide association study (GWAS) as genetic instruments and summary-level data from a published GWAS of NAFLD (1122 cases and 399,900 healthy controls) in the UK Biobank. The causal relationship was estimated with the inverse weighted method using a 4-SNP and 6-SNP instrument based on the single largest non-UK Biobank GWAS (n = 91,462) and meta-analysis (n = 121,524) of GWAS data on

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7910323 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature