Kinetic Modelling and Test-Retest Reproducibility for the Dopamine D₁R Radioligand [¹¹C]SCH23390 in Healthy and Diseased Mice.

ABSTRACT:

Purpose

Our aim in this study was to compare different non-invasive pharmacokinetic models and assess test-retest reproducibility of the radioligand [¹¹C]SCH23390 for the quantification of dopamine D₁-like receptor (D₁R) in both wild-type (WT) mice and heterozygous (HET) Q175DN mice as Huntington's disease (HD) model.

Procedures

Adult WT (n = 9) and HET (n = 14) mice underwent a 90-min [¹¹C]SCH23390 positron emission tomography (PET) scan followed by computed tomography (CT) to evaluate the pharmacokinetic modelling in healthy and diseased conditions. Additionally, 5 WT mice and 7 HET animals received a second [¹¹C]SCH23390 PET scan for test-retest reproducibility. Parallel assessment of the simplified reference tissue m

SUBMITTER: Bertoglio D 

PROVIDER: S-EPMC7910372 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature