A comparison of airway pressures for inflation fixation of developing mouse lungs for stereological analyses.

ABSTRACT: The morphometric analysis of lung structure using the principles of stereology has emerged as a powerful tool to describe the structural changes in lung architecture that accompany the development of lung disease that is experimentally modelled in adult mice. These stereological principles are now being applied to the study of the evolution of the lung architecture over the course of prenatal and postnatal lung development in mouse neonates and adolescents. The immature lung is structurally and functionally distinct from the adult lung, and has a smaller volume than does the adult lung. These differences have raised concerns about whether the inflation fixation of neonatal mouse lungs with the airway pressure (P_aw) used for the inflation fixation of adult mouse lungs may cause d

SUBMITTER: Perez-Bravo D 

PROVIDER: S-EPMC7910376 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature