Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension.

ABSTRACT: Significance: Hypertension has major health consequences, which is associated with endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) signaling in the vasculature plays an important role in maintaining vascular homeostasis. Considering the importance of NO system, this review aims to provide a brief overview of the biochemistry of members of NO signaling, including GTPCH1 [guanosine 5'-triphosphate (GTP) cyclohydrolase 1], tetrahydrobiopterin (BH₄), and eNOS. Recent Advances: Being NO signaling activators and regulators of eNOS signaling, BH₄ treatment is getting widespread attention either as potential therapeutic agents or as preventive agents. Recent clinical trials also support that BH₄

SUBMITTER: Wu Y 

PROVIDER: S-EPMC7910417 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature