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Can TP53 variant negative be high-grade serous ovarian carcinoma? A case series.

ABSTRACT: •TP53 variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry.•Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains.•Genetic reassessment through more comprehensive assays should be considered to ensure no missed rare or complex variants.•Presence of BRCA mutations can occur in TP53 variant high-grade serous ovarian cancer.

SUBMITTER: Kasherman L 

PROVIDER: S-EPMC7910505 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Can <i>TP53</i> variant negative be high-grade serous ovarian carcinoma? A case series.

Kasherman Lawrence L   Garg Swati S   Tchrakian Nairi N   Clarke Blaise B   Karakasis Katherine K   Kim Raymond H RH   Stockley Tracy L TL   Dhani Neesha N   Oza Amit M AM   Lheureux Stephanie S  

Gynecologic oncology reports 20210212

•<i>TP53</i> variant negative high-grade serous ovarian cancer is rare and can still show p53 abnormal immunohistochemistry.•Diagnostic and therapeutic considerations include pathologic, molecular and clinical domains.•Genetic reassessment through more comprehensive assays should be considered to ensure no missed rare or complex variants.•Presence of <i>BRCA</i> mutations can occur in <i>TP53</i> variant high-grade serous ovarian cancer. ...[more]

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