Quantitative modeling of multigenerational effects of chronic ionizing radiation using targeted and nontargeted effects.

ABSTRACT: Stress response signals can propagate between cells damaged by targeted effects (TE) of ionizing radiation (e.g. energy depositions and ionizations in the nucleus) and undamaged "bystander" cells, sometimes over long distances. Their consequences, called non-targeted effects (NTE), can substantially contribute to radiation-induced damage (e.g. cell death, genomic instability, carcinogenesis), particularly at low doses/dose rates (e.g. space exploration, some occupational and accidental exposures). In addition to controlled laboratory experiments, analysis of observational data on wild animal and plant populations from areas contaminated by radionuclides can enhance our understanding of radiation responses because such data span wide ranges of dose rates applied over many generations. Here

SUBMITTER: Shuryak I 

PROVIDER: S-EPMC7910614 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature