Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment.

ABSTRACT:

Background

Substantial recent advances in the comprehension of the molecular and cellular mechanisms behind asthma have evidenced the importance of the lung immune environment for disease outcome, making modulation of local immune responses an attractive therapeutic target against this pathology. Live attenuated mycobacteria, such as the tuberculosis vaccine BCG, have been classically linked with a type 1 response, and proposed as possible modulators of the type 2 response usually associated with asthma.

Methods

In this study we used different acute and chronic murine models of asthma to investigate the therapeutic efficacy of intranasal delivery of the live tuberculosis vaccines BCG and MTBVAC by regulating the lung immune environment associated with airway hyperresponsiven

SUBMITTER: Tarancon R 

PROVIDER: S-EPMC7910687 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature