New genotype invasion of dengue virus serotype 1 drove massive outbreak in Guangzhou, China.

ABSTRACT:

Background

Dengue fever is a mosquito-borne infectious disease that has caused major health problems. Variations in dengue virus (DENV) genes are important features of epidemic outbreaks. However, the associations of DENV genes with epidemic potential have not been extensively examined. Here, we assessed new genotype invasion of DENV-1 isolated from Guangzhou in China to evaluate associations with epidemic outbreaks.

Methodology/principal findings

We used DENV-1 strains isolated from sera of dengue cases from 2002 to 2016 in Guangzhou for complete genome sequencing. A neighbor-joining phylogenetic tree was constructed to elucidate the genotype characteristics and determine if new genotype invasion was correlated with major outbreaks. In our study, a new genotype invasion eve

SUBMITTER: Ma M 

PROVIDER: S-EPMC7910771 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature