Vector dynamics influence spatially imperfect genetic interventions against disease.

ABSTRACT:

Background and objectives

Genetic engineering and similar technologies offer promising new approaches to controlling human diseases by blocking transmission from vectors. However, in spatially structured populations, imperfect coverage of the vector will leave pockets in which the parasite may persist. Movement by humans may disrupt this local persistence and facilitate eradication when these pockets are small, spreading parasite reproduction outside unprotected areas and into areas that block its reproduction. Here, we consider the sensitivity of this process to biological details: do simple generalities emerge that may facilitate interventions?

Methodology

We develop formal mathematical models of this process similar to standard Ross-Macdonald models, but (i) specifying sp

SUBMITTER: Yuksel MK 

PROVIDER: S-EPMC7910803 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature