Advancements in mRNA Encoded Antibodies for Passive Immunotherapy.

ABSTRACT: Monoclonal antibodies are the fastest growing therapeutic class in medicine today. They hold great promise for a myriad of indications, including cancer, allergy, autoimmune and infectious diseases. However, the wide accessibility of these therapeutics is hindered by manufacturing and purification challenges that result in high costs and long lead times. Efforts are being made to find alternative ways to produce and deliver antibodies in more expedient and cost-effective platforms. The field of mRNA has made significant progress in the last ten years and has emerged as a highly attractive means of encoding and producing any protein of interest in vivo. Through the natural role of mRNA as a transient carrier of genetic information for translation into proteins, in vivo expression of mRNA-en

SUBMITTER: Deal CE 

PROVIDER: S-EPMC7910832 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature