Calcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical Trials.

ABSTRACT: Recent systematic reviews and meta-analyses of randomized, double-blind, placebo-controlled trials (double-blind, placebo-controlled RCTs) have reported controversial findings regarding the associations between calcium supplements on the risk of cardiovascular disease (CVD). This meta-analysis aimed to investigate the association between them. We searched PubMed, EMBASE, the Cochrane Library, and the bibliographies of relevant articles for double-blind, placebo-controlled RCTs in November, 2020. Relative risks (RRs) with 95% confidence intervals (CIs) for the risk of cardiovascular disease were calculated using a random effects model. The main outcomes were CVD, coronary heart disease (CHD), and cerebrovascular disease. A total of 13 double-blind, placebo-controlled RCTs (n = 28,935 partic

SUBMITTER: Myung SK 

PROVIDER: S-EPMC7910980 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature