Old Question Revisited: Are High-Protein Diets Safe in Pregnancy?

ABSTRACT: A previous randomized dietary intervention in pregnant women from the 1970s, the Harlem Trial, reported retarded fetal growth and excesses of very early preterm births and neonatal deaths among those receiving high-protein supplementation. Due to ethical challenges, these findings have not been addressed in intervention settings. Exploring these findings in an observational setting requires large statistical power due to the low prevalence of these outcomes. The aim of this study was to investigate if the findings on high protein intake could be replicated in an observational setting by combining data from two large birth cohorts. Individual participant data on singleton pregnancies from the Danish National Birth Cohort (DNBC) (n = 60,141) and the Norwegian Mother, Father and Child Cohort

SUBMITTER: Halldorsson TI 

PROVIDER: S-EPMC7911198 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature