Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats.

ABSTRACT: The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt

SUBMITTER: Wang J 

PROVIDER: S-EPMC7911279 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature