The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma.

ABSTRACT:

Background

Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. This article is aimed at formulating an IAG signature to estimate prognosis of melanoma.

Methods

434 melanoma patients were extracted from The Cancer Genome Atlas (TCGA) database, and 1811 IAGs were downloaded from the ImmPort database in our retrospective study. The Cox regression analysis and LASSO regression analysis were utilized to establish a prognostic IAG signature. The Kaplan-Meier (KM) survival analysis was performed, and the time-dependent receiver operating characteristic curve (ROC) analysis was further applied to assess the predictive va

SUBMITTER: Song LB 

PROVIDER: S-EPMC7911606 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature