Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects.

ABSTRACT: This study was carried out to pursue the observation that the level of gene expression is affected by gene length in the human genome. As transcription is a time-dependent process, it is expected that gene expression will be inversely related to gene length, and this is found to be the case. Here, I describe the results of studies performed to test whether the gene length/gene expression linkage is affected by two factors, the chromosome where the gene is located and the tissue where it is expressed. Studies were performed with a database of 3538 human genes that were divided into short, midlength, and long groups. Chromosome groups were then compared in the expression level of genes with the same length. A similar analysis was performed with 19 human tissues. Tissue-specific groups were c

SUBMITTER: Brown JC 

PROVIDER: S-EPMC7911607 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature