The Role of Uniform Meropenem Usage in Acinetobacter baumannii Clone Replacement.

ABSTRACT: The dominant carbapenem resistant Acinetobacter baumannii harboring bla_OXA-23-like carbapenemase was replaced by bla_OXA-40-like carriers in a Hungarian tertiary-care center with high meropenem but relatively low imipenem use. We hypothesized that alterations in antibiotic consumption may have contributed to this switch. Our workgroup previous study examined the relation between resistance spiral and the antibiotic consumption, and the results suggest that the antibiotic usage provoked the increasing resistance in case of A. baumannii. We aimed at measuring the activity of imipenem and meropenem to compare the selection pressure exerted by the different carbapenems in time-kill assays. Strain replacement was confirmed by whole genome sequenc

SUBMITTER: Balazs B 

PROVIDER: S-EPMC7911629 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature