Green Salad Intake Is Associated with Improved Oral Cancer Survival and Lower Soluble CD44 Levels.

ABSTRACT: Deficiencies in fruit and vegetable intake have been associated with oral cancer (oral cavity and oropharyngeal). Salivary rinses contain measurable biomarkers including soluble CD44 (solCD44) and total protein, which are known markers of oral cancer risk. This study investigates the effect of nutritional factors on solCD44 and protein levels to evaluate oral cancer risk and survival. We evaluated solCD44 and protein levels from 150 patients with oral and oropharyngeal squamous cell carcinoma and 150 frequency-matched controls. We subsequently characterized the effect of food group consumption and these biomarkers on progression-free survival (PFS) and overall survival (OS). Patients reported eating fewer servings of salad (p = 0.015), while controls reported eating fewer servings of potat

SUBMITTER: Bell EB 

PROVIDER: S-EPMC7911809 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature