Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women.

ABSTRACT:

Background

Premature menopause is an independent risk factor for cardiovascular disease in women, but mechanisms underlying this association remain unclear. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of hematopoietic cells with leukemogenic mutations without detectable malignancy, is associated with accelerated atherosclerosis. Whether premature menopause is associated with CHIP is unknown.

Methods

We included postmenopausal women from the UK Biobank (n=11 495) aged 40 to 70 years with whole exome sequences and from the Women's Health Initiative (n=8111) aged 50 to 79 years with whole genome sequences. Premature menopause was defined as natural or surgical menopause occurring before age 40 years. Co-primary outcomes were the presence of

SUBMITTER: Honigberg MC 

PROVIDER: S-EPMC7911856 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature