Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects.

ABSTRACT: Obstructive airway diseases, e.g., chronic obstructive pulmonary disease (COPD) and asthma, represent leading causes of morbidity and mortality worldwide. However, the efficacy of currently available inhaled therapeutics is not sufficient for arresting disease progression and decreasing mortality, hence providing an urgent need for development of novel therapeutics. Local delivery to the airways via inhalation is promising for novel drugs, because it allows for delivery directly to the target site of action and minimizes systemic drug exposure. In addition, novel drug modalities like RNA therapeutics provide entirely new opportunities for highly specific treatment of airway diseases. Here, we review state of the art of conventional inhaled drugs used for the treatment of COPD and asthma wi

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7912103 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature