Structural Recognition of Triple-Stranded DNA by Surface-Enhanced Raman Spectroscopy.

ABSTRACT: Direct, label-free analysis of nucleic acids via surface-enhanced Raman spectroscopy (SERS) has been continuously expanding its range of applications as an intriguing and powerful analytical tool for the structural characterization of diverse DNA structures. Still, interrogation of nucleic acid tertiary structures beyond the canonical double helix often remains challenging. In this work, we report for the first time the structural identification of DNA triplex structures. This class of nucleic acids has been attracting great interest because of their intriguing biological functions and pharmacological potential in gene therapy, and the ability for precisely engineering DNA-based functional nanomaterials. Herein, structural discrimination of the triplex structure against its duplex and tert

SUBMITTER: Guerrini L 

PROVIDER: S-EPMC7912272 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature