Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring.

ABSTRACT: The increasing prevalence of colonic diseases calls for a better understanding of the various colonic drug absorption barriers of colon-targeted formulations, and for reliable in vitro tools that accurately predict local drug disposition. In vivo relevant incubation conditions have been shown to better capture the composition of the limited colonic fluid and have resulted in relevant degradation and dissolution kinetics of drugs and formulations. Furthermore, drug hurdles such as efflux transporters and metabolising enzymes, and the presence of mucus and microbiome are slowly integrated into drug stability- and permeation assays. Traditionally, the well characterized Caco-2 cell line and the Ussing chamber technique are used to assess the absorption characteristics of small drug molecules.

SUBMITTER: Lemmens G 

PROVIDER: S-EPMC7912393 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature