Ontology highlight
ABSTRACT:
SUBMITTER: Lenz M
PROVIDER: S-EPMC7912627 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lenz Max M Kaun Christoph C Krychtiuk Konstantin A KA Haider Patrick P Brekalo Mira M Maier Nadine N Goederle Laura L Binder Christoph J CJ Huber Kurt K Hengstenberg Christian C Wojta Johann J Hohensinner Philipp J PJ Speidl Walter S WS
Biomedicines 20210127 2
Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-R -/- mice were fed a high-fat diet for 14 weeks. After 6 weeks mice were randomly allocated to treatment with nicorandil (10 mg/kg/day) or tap water. Nicorandil treatment led to a more stable plaque phenotype, displaying an increased thickness of the fibrous c ...[more]