Four pleiotropic loci associated with fat mass and lean mass.

ABSTRACT:

Background

Fat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.

Methods

We performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N = 370 097).

Results

We identified four loci that were significant at the genome-wide significance (GWS, α = 5.0 × 10^-8) level at the discovery meta-analysis, and successfully replicated in the replication sample: 2q36.3 (rs1024137, p_discovery = 3.32 × 10^-8, p_replication = 4.07 × 10^-13), 5q13.1 (rs4976033, p

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7912634 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature