Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp. SV 21.

ABSTRACT: The manuscript investigated the isolation, characterization and anti-infective potential of valinomycin (3), streptodepsipeptide P11A (2), streptodepsipeptide P11B (1), and one novel valinomycin analogue, streptodepsipeptide SV21 (4), which were all produced by the Gram-positive strain Streptomycescavourensis SV 21. Although the exact molecular weight and major molecular fragments were recently reported for compound 4, its structure elucidation was not based on compound isolation and spectroscopic techniques. We successfully isolated and elucidated the structure based on the MS² fragmentation pathways as well as ¹H and ¹³C NMR spectra and found that the previously reported structure of compound 4 diffe

SUBMITTER: Wibowo JT 

PROVIDER: S-EPMC7912928 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature