CDX2 and Reg IV expression and correlation in gastric cancer.

ABSTRACT:

Background

Ectopic expression of CDX2 is associated with the development and progression of gastric cancer. Previous studies showed that CDX2 may be an upstream regulator of Reg IV expression in gastric cancer, and our previous report showed that Reg IV upregulated SOX9 expression and enhanced cell migration and invasion in gastric cancer cells. However, the regulatory roles of CDX2 have not been clarified in gastric cancer, and the correlation between CDX2 and Reg IV requires further study.

Methods

CDX2 and Reg IV were examined in gastric cancer specimens and paired adjacent tissues via real-time PCR and immunohistochemistry (IHC). The association between CDX2 and Reg IV was assessed using the χ²-test and Spearman's rank correlation. To verify their relationship,

SUBMITTER: Chai D 

PROVIDER: S-EPMC7913228 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature