Interplay between Humoral and CLA⁺ T Cell Response against Candida albicans in Psoriasis.

ABSTRACT: Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA^- cutaneous lymphocyte antigen (CLA)^+/- T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls.

SUBMITTER: de Jesus-Gil C 

PROVIDER: S-EPMC7913574 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature