A Meta-Analysis of the Effects of High-LET Ionizing Radiations in Human Gene Expression.

ABSTRACT: The use of high linear energy transfer (LET) ionizing radiation (IR) is progressively being incorporated in radiation therapy due to its precise dose localization and high relative biological effectiveness. At the same time, these benefits of particle radiation become a high risk for astronauts in the case of inevitable cosmic radiation exposure. Nonetheless, DNA Damage Response (DDR) activated via complex DNA damage in healthy tissue, occurring from such types of radiation, may be instrumental in the induction of various chronic and late effects. An approach to elucidating the possible underlying mechanisms is studying alterations in gene expression. To this end, we identified differentially expressed genes (DEGs) in high Z and high energy (HZE) particle-, γ-ray- and X-ray-exposed healthy

SUBMITTER: Michalettou TD 

PROVIDER: S-EPMC7913660 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature