Synthesis of Cyclic Enones by Allyl-Palladium-Catalyzed α,β-Dehydrogenation.

ABSTRACT: The use of allyl-palladium catalysis for the one-step α,β-dehydrogenation of ketones via their zinc enolates is reported. The optimized protocol utilizes commercially available Zn(TMP)₂ as base and diethyl allyl phosphate as oxidant. Notably, this transformation operates under salt-free conditions and tolerates a diverse scope of cycloalkanones.

SUBMITTER: Huang D 

PROVIDER: S-EPMC7913890 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature