Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Mull.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking.

ABSTRACT: Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. is a well-known African medicinal plant traditionally used for various healing purposes. In the present study, methanolic, ethyl acetate and infusion extracts of A. cordifolia leaves were studied for their total phenolic and flavonoid contents and screened for their chemical composition. Moreover, the enzyme (acetyl- and butyryl-cholinesterases, α-amylase, α-glucosidase, and tyrosinase) inhibitory and cytotoxicity activities on HepG2: human hepatocellular carcinoma cells, B16 4A5: murine melanoma cells, and S17: murine bone marrow (normal) cells of extracts were evaluated. Finally, components-targets and docking analyzes were conducted with the aim to unravel the putative mechanisms underlying the observed bio-pharmacologic

SUBMITTER: Sinan KI 

PROVIDER: S-EPMC7913913 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature