Familial Clustering of Erosive Hand Osteoarthritis in a Large Statewide Cohort.

ABSTRACT:

Objective

Erosive hand osteoarthritis (OA) is a severe and rapidly progressing subset of hand OA. Its etiology remains largely unknown, which has hindered development of successful treatments. This study was undertaken to test the hypothesis that erosive hand OA demonstrates familial clustering in a large statewide population linked to genealogical records, and to determine the association of potential risk factors with erosive hand OA.

Methods

Patients diagnosed as having erosive hand OA were identified by searching 4,741,840 unique medical records from a comprehensive statewide database, the Utah Population Database (UPDB). Affected individuals were mapped to pedigrees to identify high-risk families with excess clustering of erosive hand OA as defined by a familial standar

SUBMITTER: Kazmers NH 

PROVIDER: S-EPMC7914133 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature