Quantitative ¹H and ²³Na muscle MRI in Facioscapulohumeral muscular dystrophy patients.

ABSTRACT:

Objective

Our aim was to assess the role of quantitative ¹H and ²³Na MRI methods in providing imaging biomarkers of disease activity and severity in patients with Facioscapulohumeral muscular dystrophy (FSHD).

Methods

We imaged the lower leg muscles of 19 FSHD patients and 12 controls with a multimodal MRI protocol to obtain STIR-T₂w images, fat fraction (FF), water T₂ (wT₂), water T₁ (wT₁), tissue sodium concentration (TSC), and intracellular-weighted sodium signal (inversion recovery (IR) and triple quantum filter (TQF) sequence). In addition, the FSHD patients underwent muscle strength testing.

Results

Imaging biomarkers related with water mobility (wT₁ and wT₂) and i

SUBMITTER: Gerhalter T 

PROVIDER: S-EPMC7914168 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature