Seizures associated with antibodies against cell surface antigens are acute symptomatic and not indicative of epilepsy: insights from long-term data.

ABSTRACT:

Background

Clinicians have questioned whether any disorder involving seizures and neural antibodies should be called "(auto)immune epilepsy." The concept of "acute symptomatic seizures" may be more applicable in cases with antibodies against neural cell surface antigens. We aimed at determining the probability of achieving seizure-freedom, the use of anti-seizure medication (ASM), and immunotherapy in patients with either constellation. As a potential pathophysiological correlate, we analyzed antibody titer courses.

Methods

Retrospective cohort study of 39 patients with seizures and neural antibodies, follow-up ≥ 3 years.

Results

Patients had surface antibodies against the N-methyl-D-aspartate receptor (NMDAR, n = 6), leucine-rich glioma inactivated protein 1 (LGI1, n

SUBMITTER: Rada A 

PROVIDER: S-EPMC7914192 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature