Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis.

ABSTRACT:

Objective

Eicosanoids modulate inflammation via complex networks involving different pathways and downstream mediators, including oxylipins. Although altered eicosanoids are linked to rheumatoid arthritis (RA), suggesting that metabolization is enhanced, the role of oxylipins in disease stratification remains unexplored. This study was undertaken to characterize oxylipin networks during the earliest stages of RA and evaluate their associations with clinical features and treatment outcomes.

Methods

In total, 60 patients with early RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 criteria), 11 individuals with clinically suspect arthralgia (CSA), and 28 healthy control subjects were recruited. Serum samples were collected at the tim

SUBMITTER: Rodriguez-Carrio J 

PROVIDER: S-EPMC7914204 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature