Unexpectedly Low Natriuretic Peptide Levels in Patients With Heart Failure.

ABSTRACT:

Objectives

The purpose of this study was to determine the frequency of unexpectedly low natriuretic peptide (NP) levels in a clinical population.

Background

Higher NP concentrations are typically observed as a compensatory response to elevated cardiac wall stress. Under these conditions, low NP levels may be indicative of a "NP deficiency."

Methods

We identified 3 clinical scenarios in which high B-type natriuretic peptide (BNP) levels would be expected: 1) hospitalization for heart failure (HF); 2) abnormal cardiac structure or function; or 3) abnormal hemodynamics. In Vanderbilt's electronic health record, 47,970 adult patients had BNP measurements. A total of 13,613 patients had at least 1 of the 3 conditions (hospitalized HF, n = 9,153; abnormal cardiac structure/

SUBMITTER: Bachmann KN 

PROVIDER: S-EPMC7914207 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature