Effects of ketogenic diet and ketone monoester supplement on acute alcohol withdrawal symptoms in male mice.

ABSTRACT:

Rationale

After alcohol ingestion, the brain partly switches from consumption of glucose to consumption of the alcohol metabolite acetate. In heavy drinkers, the switch persists after abrupt abstinence, leading to the hypothesis that the resting brain may be "starved" when acetate levels suddenly drop during abstinence, despite normal blood glucose, contributing to withdrawal symptoms. We hypothesized that ketone bodies, like acetate, could act as alternative fuels in the brain and alleviate withdrawal symptoms.

Objectives

We previously reported that a ketogenic diet during alcohol exposure reduced acute withdrawal symptoms in rats. Here, our goals were to test whether (1) we could reproduce our findings, in mice and with longer alcohol exposure; (2) ketone bodies alone are

SUBMITTER: Bornebusch AB 

PROVIDER: S-EPMC7914216 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature