Comparative analysis of dimethyl fumarate and fingolimod in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Dimethyl fumarate and fingolimod are oral disease modifying treatments (DMTs) that reduce relapse activity and slow disability worsening in relapsing-remitting multiple sclerosis (RRMS).

Objective

To compare the effectiveness of dimethyl fumarate and fingolimod in a real-world setting, where both agents are licensed as a first-line DMT for the treatment of RRMS.

Methods

We identified patients with RRMS commencing dimethyl fumarate or fingolimod in the Swiss Federation for Common Tasks of Health Insurances (SVK) Registry between August 2014 and July 2019. Propensity score-matching was applied to select subpopulations with comparable baseline characteristics. Relapses and disability outcomes were compared in paired, pairwise-censored analyses.

Results

SUBMITTER: Lorscheider J 

PROVIDER: S-EPMC7914245 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature