Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis.

ABSTRACT: We conducted a meta-analysis of preclinical studies that tested left ventricular assist device (LVAD) therapy for reducing myocardial infarct size in experimental acute myocardial infarction (AMI). Twenty-six articles were included with a total of 488 experimental animal subjects. The meta-analysis showed that infarct size was significantly decreased by LVAD support compared to control animals (SDM, - 2.19; 95% CI, - 2.70 to - 1.69; P < 0.001). The meta-regression analysis demonstrated a high degree of heterogeneity associated with time from coronary artery occlusion to LVAD support, which correlated positively with infarct size. Subgroup analysis suggested smaller infarct size in LVAD therapies that withdrew blood from left heart than those from right heart. The proportion of left ventric

SUBMITTER: Miyashita S 

PROVIDER: S-EPMC7914262 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature