Macrophages expedite cell proliferation of prostate intraepithelial neoplasia through their downstream target ERK.

ABSTRACT: The risk factors for prostate cancer include a high-fat diet and obesity, both of which are associated with an altered cell environment including increased inflammation. It has been shown that chronic inflammation due to a high-fat diet or bacterial infection has the potential to accelerate prostate cancer as well as its precursor, prostatic intraepithelial neoplasia (PIN), development. However, the underlying mechanism of how chronic inflammation promotes prostate cancer development, especially PIN, remains unclear. In this study, we showed that more macrophages were present in PIN areas as compared to the normal areas of human prostate. When co-culturing PIN cells with macrophages in 3D, more PIN cells had nuclear localized cyclin D1, indicating that macrophages enhanced PIN cell prolife

SUBMITTER: Thomas MU 

PROVIDER: S-EPMC7914274 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature