Evaluation of [⁶⁸Ga]Ga-PSMA PET/CT images acquired with a reduced scan time duration in prostate cancer patients using the digital biograph vision.

ABSTRACT:

Aim

[⁶⁸Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered tracer activity due to, for instance, its higher sensitivity and improved time coincidence resolution. It might thereby expand [⁶⁸Ga]Ga-PSMA-11 PET/CT that is currently limited by ⁶⁸Ge/⁶⁸Ga-generator yield. Our aim was to clinically evaluate the influence of a reduced scan time duration in combination with different image reconstruction algorithms on the diagnostic performance.

Methods

Twenty prostate cancer patients (11 for biochemical recurrence, 5 for initial staging, 4 for metastatic disease) sequentially underwent [

SUBMITTER: Weber M 

PROVIDER: S-EPMC7914332 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature