Grading Evolution and Contemporary Prognostic Biomarkers of Clinically Significant Prostate Cancer.

ABSTRACT: Gleason grading remains the strongest prognostic parameter in localized prostate adenocarcinoma. We have here outlined the evolution and contemporary practices in pathological evaluation of prostate tissue samples for Gleason score and Grade group. The state of more observer-independent grading methods with the aid of artificial intelligence is also reviewed. Additionally, we conducted a systematic review of biomarkers that hold promise in adding independent prognostic or predictive value on top of clinical parameters, Grade group and PSA. We especially focused on hard end points during the follow-up, i.e., occurrence of metastasis, disease-specific mortality and overall mortality. In peripheral blood, biopsy-detected prostate cancer or in surgical specimens, we can conclude that there are

SUBMITTER: Sopyllo K 

PROVIDER: S-EPMC7914622 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature